The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 09, 2022

Filed:

Apr. 03, 2019
Applicants:

Universite DE Bretagne Occidentale, Brest, FR;

Centre Hospitalier Regional Universitaire DE Brest, Brest, FR;

Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;

Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;

Institut Curie, Paris, FR;

Université DE Paris, Paris, FR;

Univ Paris Xiii Paris-nord Villetaneuse, Villetaneuse, FR;

Universite Paris-saclay, Saint Aubin, FR;

Inventors:

Marc Blondel, Brest, FR;

Alicia Quillevere, Guipavas, FR;

Cécile Voisset, Brest, FR;

Maria José Lista, Paris, FR;

Robin Fahraeus, Paris, FR;

Chrysoula Daskalogianni, Paris, FR;

Rodrigo Prado-Martins, Paris, FR;

Marie-Paule Teulade-Fichou, Paris, FR;

Anton Granzhan, Courbevoie, FR;

Claire Beauvineau, Chilly Mazarin, FR;

Oksana Reznichenko, Saint-Rémy-les-Chevreuse, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61P 31/20 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 31/444 (2006.01); A61K 31/4745 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 9/0019 (2013.01); A61K 31/444 (2013.01); A61K 31/4745 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); A61P 31/20 (2018.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Arand Armay be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Yand Zare independently CH or NR, provided that al least one of Yand Zis NRand at least one of Yand Zis CH,and R, R, R, Xand L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.


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