The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Sep. 20, 2017
Applicant:
Nanyang Technological University, Singapore, SG;
Inventors:
Ho Sup Yoon, Singapore, SG;
Sreekanth Rajan, Singapore, SG;
Hui Ting Toh, Singapore, SG;
Xuewei Liu, Singapore, SG;
Hui Yao, Singapore, SG;
Assignee:
Nanyang Technological University, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/191 (2006.01); C07C 59/90 (2006.01); C07K 14/705 (2006.01); G16B 35/20 (2019.01);
U.S. Cl.
CPC ...
A61K 31/191 (2013.01); C07C 59/90 (2013.01); C07K 14/70567 (2013.01); G16B 35/20 (2019.02);
Abstract
Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.