The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 02, 2022

Filed:

Dec. 31, 2019
Applicant:

Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);

Inventors:

Ye Hu, New Orleans, LA (US);

Dali Sun, West Fargo, ND (US);

Christopher Lyon, Tempe, AZ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G02B 21/26 (2006.01); G01N 1/31 (2006.01); G01N 1/44 (2006.01); G01N 1/38 (2006.01); G02B 21/00 (2006.01); G01K 7/02 (2021.01); G01N 33/483 (2006.01); G02B 21/36 (2006.01); G02B 21/10 (2006.01);
U.S. Cl.
CPC ...
G02B 21/26 (2013.01); G01K 7/02 (2013.01); G01N 1/312 (2013.01); G01N 1/44 (2013.01); G01N 33/483 (2013.01); G02B 21/365 (2013.01); G01N 2001/386 (2013.01); G02B 21/0088 (2013.01); G02B 21/10 (2013.01);
Abstract

The present disclosure relates a low magnification dark-field microscope system and method for producing a dark-field image. The method includes transferring a biological specimen to a surface of a sample plate, and pre-treating the biological specimen using one or more pre-treatment steps selected from (1) heating the biological specimen using a heating device; (2) applying ultrasound energy using an ultrasound transducer and ultrasound generator; and (3) doping the biological specimen with a metallic nanoparticle. Following pre-treatment, the method includes imaging a region of interest the biological specimen on the sample plate using a dark-field microscope to generate a dark-field image of the biological specimen.


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