The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Jan. 25, 2019
Applicant:
Emory University, Atlanta, GA (US);
Inventors:
Assignee:
Emory University, Atlanta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/564 (2006.01); G01N 33/52 (2006.01); C07K 14/08 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01); C12N 5/0783 (2010.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); G01N 33/577 (2006.01); C07K 16/10 (2006.01); C07K 14/005 (2006.01); C12Q 1/66 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56983 (2013.01); C07K 14/005 (2013.01); C07K 16/10 (2013.01); C12N 5/0646 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C12Q 1/66 (2013.01); G01N 33/52 (2013.01); G01N 33/564 (2013.01); G01N 33/577 (2013.01); G01N 33/6854 (2013.01); C07K 14/08 (2013.01); C07K 16/2803 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C12N 2760/14122 (2013.01);
Abstract
This disclosure relates to assays for detecting activating antibodies in a sample that are capable of antibody-dependent cell-mediated cytotoxicity. In certain embodiments, this disclosure relates to target cells comprising an antigen on the exterior of the cells and a luciferase inside the cells. In certain embodiments, the antigen is an Ebola-virus glycoprotein. In certain embodiments, this disclosure relates to detecting changes in chemiluminescence of the luciferase as an indication of activating antibodies in a sample capable of cell lysis when mixed with effector cells.