The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 02, 2022

Filed:

Mar. 06, 2019
Applicant:

Genomatica, Inc., San Diego, CA (US);

Inventors:

Stephen J. Van Dien, Encinitas, CA (US);

Anthony P. Burgard, Elizabeth, PA (US);

Robert Haselbeck, San Diego, CA (US);

Catherine J. Pujol-Baxley, Santee, CA (US);

Wei Niu, Lincoln, NE (US);

John D. Trawick, La Mesa, CA (US);

Harry Yim, Vista, CA (US);

Mark J. Burk, San Diego, CA (US);

Robin E. Osterhout, San Diego, CA (US);

Jun Sun, San Diego, CA (US);

Assignee:

Genomatica, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/18 (2006.01); C07D 307/33 (2006.01); C12P 17/04 (2006.01); C07D 307/08 (2006.01); C07D 207/267 (2006.01); C12P 17/10 (2006.01); C12N 9/04 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12N 9/16 (2006.01); C12N 9/88 (2006.01); C12N 9/00 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12P 7/18 (2013.01); C07D 207/267 (2013.01); C07D 307/08 (2013.01); C07D 307/33 (2013.01); C12N 9/001 (2013.01); C12N 9/0006 (2013.01); C12N 9/0008 (2013.01); C12N 9/13 (2013.01); C12N 9/16 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12N 15/52 (2013.01); C12P 17/04 (2013.01); C12P 17/10 (2013.01);
Abstract

The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.


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