The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Feb. 08, 2019
Applicant:
Sangamo Therapeutics, Inc., Richmond, CA (US);
Inventors:
Russell DeKelver, Richmond, CA (US);
Ivan Krivega, Richmond, CA (US);
Jeffrey C. Miller, Richmond, CA (US);
Lei Zhang, Richmond, CA (US);
Assignee:
Sangamo Therapeutics, Inc., Brisbane, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12N 7/00 (2006.01); A61K 38/46 (2006.01); A61K 48/00 (2006.01); C12N 9/64 (2006.01); C12N 9/16 (2006.01); C12N 9/24 (2006.01); A61K 38/47 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); A61K 38/4846 (2013.01); A61K 48/0066 (2013.01); C12N 7/00 (2013.01); C12N 9/16 (2013.01); C12N 9/2402 (2013.01); C12N 9/644 (2013.01); C12Y 301/06013 (2013.01); C12Y 302/01076 (2013.01); C12Y 304/21022 (2013.01); C12N 2750/14343 (2013.01); C12N 2800/80 (2013.01);
Abstract
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.