The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Dec. 20, 2018
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Amod A. Sarnaik, Tampa, FL (US);
Jeffrey S. Weber, Tampa, FL (US);
Shari Pilon-Thomas, Tampa, FL (US);
Laszlo G. Radvanyi, Lutz, FL (US);
Jessica Ann Chacon, Philadelphia, PA (US);
James J. Mule, Odessa, FL (US);
MacLean S. Hall, Tampa, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
Board nf Regents The Inivercitvof Texas Cvctom, Austin, TX (US);
Abstract
Disclosed herein is a method for ex vivo expanding tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). The method involves culturing tumor fragments from the subject in a culture medium containing IL-2 and a 41BB agonist in an amount effective to expand tumor-infiltrating lymphocytes with enriched tumor-reactivity and specificity. Also disclosed is a method for treating a tumor in a subject that involves treating the subject with nonmyeloablative lymphodepleting chemotherapy, and administering tumor-infiltrating lymphocytes expanded by the disclosed methods.