The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Nov. 26, 2018
Applicant:
Purdue Pharma L.p., Stamford, CT (US);
Inventors:
Daniel A. Soltis, Cleveland Heights, OH (US);
Thomas Mehrling, Riehen, CH;
Richard John Buick, Belfast, GB;
Assignee:
Purdue Pharma L.P., Stamford, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/36 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/36 (2013.01); A61K 47/6803 (2017.08); A61K 47/6843 (2017.08); A61P 35/00 (2018.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present disclosure provides humanized antibodies and antibody-drug conjugates that specifically bind to human tissue factor, and which do not inhibit tissue factor mediated blood coagulation compared to a normal plasma control. Further described are methods of making and methods of using the disclosed humanized antibodies and antibody-drug conjugates in the treatment of cancer.