The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Nov. 13, 2019
Applicant:
Yale University, New Haven, CT (US);
Inventor:
Faye A. Rogers, Norwalk, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07K 16/30 (2006.01); A61K 47/68 (2017.01); A61K 47/54 (2017.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C07K 16/3015 (2013.01); A61K 47/543 (2017.08); A61K 47/6807 (2017.08); C12N 15/113 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C12N 2310/15 (2013.01);
Abstract
Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of p53-depleted or p53-mutated cancer cells that have amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome.