The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Aug. 22, 2019
Applicant:
Seagen, Inc., Bothell, WA (US);
Inventors:
Julia C. Piasecki, Bothell, WA (US);
Courtney Beers, Bothell, WA (US);
Scott Peterson, Bothell, WA (US);
Bianka Prinz, Lebanon, NH (US);
Shyra Gardai, Bothell, WA (US);
Assignee:
Seagen Inc., Bothell, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 2317/31 (2013.01); C07K 2317/32 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/734 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
Isolated antibodies that bind to human TIGIT (T-cell immunoreceptor with Ig and ITIM domains) are provided. In some embodiments, the antibody has a binding affinity (K) for human TIGIT of less than 5 nM. In some embodiments, the anti-TIGIT antibody blocks binding of CD155 and/or CD112 to TIGIT. In some embodiments, the antibodies are afucosylated.