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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11401304 B1

PDFFull Text
Date of Patent:
Aug. 02, 2022

Filed:

Dec. 15, 2016

Cyclic ntcp-targeting peptides and their uses as entry inhibitors

Applicant:

Ruprecht-karls-universität Heidelberg, Heidelberg, DE;

Inventors:

Stephan Urban, Neustadt/Weinstrasse, DE;

Yi Ni, Eppelheim, DE;

Walter Mier, Bensheim, DE;

Assignee:

RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, Heidelberg, DE;

Attorney:

Saliwanchik, Lloyd & Eisenschenk

Primary Examiner:

Sudhakar Katakam

Assistant Examiner:

Zachary J Miknis

Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 14/005 (2006.01); A61K 51/08 (2006.01); A61K 49/00 (2006.01); C07K 7/64 (2006.01); C07K 7/50 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); A61P 31/20 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); A61K 49/0056 (2013.01); A61K 51/088 (2013.01); A61P 31/20 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 7/50 (2013.01); C07K 7/64 (2013.01); C07K 14/005 (2013.01); A61K 38/00 (2013.01); C12N 2730/10122 (2013.01); C12N 2730/10133 (2013.01); C12N 2730/10134 (2013.01); C12N 2730/10141 (2013.01); Y02A 50/30 (2018.01);
Abstract

The present invention relates to cyclic NTCP targeting peptides which are preS-derived peptides of hepatitis B virus (HBV). The present invention further relates to pharmaceutical compositions comprising at least one cyclic peptide. The present invention further relates to medical uses of said cyclic peptides and the pharmaceutical compositions, such as in the diagnosis, prevention and/or treatment of a liver disease or condition, and/or in the inhibition of HBV and/or HDV infection. The present invention further relates to methods of diagnosis, prevention and/or treatment of a liver disease or condition and/or the inhibition of HBV and/or HDV infection.

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