The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Mar. 18, 2019
Virginia Commonwealth University, Richmond, VA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Martin K. Safo, Richmond, VA (US);
Yan Zhang, Glen Allen, VA (US);
Piyusha Pradeep Pagare, Richmond, VA (US);
Guoyan Xu, Henrico, VA (US);
Mohini Ghatge, Glen Allen, VA (US);
Jurgen Venitz, Richmond, VA (US);
Osheiza Abdulmalik, Wynnewood, PA (US);
VIRGINIA COMMONWEALTH UNIVERSITY, Richmond, VA (US);
THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US);
Abstract
Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are based on vanillin which is chemically modified to increase bioavailability and activity, e.g. so that the compounds bind to the F helix of hemoglobin (Hb) and prevent adhesion of red blood cells (RBCs).