The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
Aug. 11, 2020
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Eric M. Gale, Charlestown, MA (US);
Peter Caravan, Cambridge, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/055 (2006.01); A61K 49/08 (2006.01); A61K 49/10 (2006.01); A61K 49/14 (2006.01); C07D 213/87 (2006.01); C07D 233/58 (2006.01); C07D 213/40 (2006.01); C07K 7/08 (2006.01); C07D 213/65 (2006.01); C07D 213/80 (2006.01); C07D 217/14 (2006.01); C07D 235/14 (2006.01); C07D 213/68 (2006.01); C07K 7/06 (2006.01); G16H 10/40 (2018.01); C07F 13/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/085 (2013.01); A61K 49/103 (2013.01); A61K 49/14 (2013.01); C07D 213/40 (2013.01); C07D 213/65 (2013.01); C07D 213/68 (2013.01); C07D 213/80 (2013.01); C07D 213/87 (2013.01); C07D 217/14 (2013.01); C07D 233/58 (2013.01); C07D 235/14 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); G16H 10/40 (2018.01); A61K 49/101 (2013.01); C07F 13/005 (2013.01);
Abstract
Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.