The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 02, 2022

Filed:

Sep. 02, 2021
Applicants:

Bolt Biotherapeutics, Inc., Redwood City, CA (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Shelley Erin Ackerman, Redwood City, CA (US);

Michael N. Alonso, Redwood City, CA (US);

David Y. Jackson, Redwood City, CA (US);

Arthur Lee, Redwood City, CA (US);

Edgar George Engleman, Atherton, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6835 (2017.08); A61K 39/395 (2013.01); A61K 47/6801 (2017.08); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6863 (2017.08); A61P 35/00 (2018.01);
Abstract

The invention provides an immunoconjugate of formula: or pharmaceutically acceptable salt thereof, wherein subscript r is an integer from 1 to 10, subscript n is an integer from about 2 to about 25, and 'Ab' is an antibody construct that has an antigen binding domain that binds HER2. The invention further provides compositions comprising and methods of treating cancer with the immunoconjugate.


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