The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
May. 05, 2017
The Regents of the University of California, Oakland, CA (US);
The Trustees of Princeton University, Princeton, NJ (US);
The Simons Foundation, Inc., New York, NY (US);
Wendell A. Lim, San Francisco, CA (US);
Olga G. Troyanskaya, Princeton, NJ (US);
Benjamin VanderSluis, New York, NY (US);
Ruth Dannenfelser, Princeton, NJ (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
THE TRUSTEES OF PRINCETON UNIVERSITY, Princeton, NJ (US);
THE SIMONS FOUNDATION INC., New York, NY (US);
Abstract
The present disclosure provides an immune cell genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a system two antigen-triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a method of killing a target cancer cell, using a genetically modified immune cell or a system of the present disclosure. The present disclosure provides a computational method to identify target antigen pairs on a cancer cell.