The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2022
Filed:
May. 31, 2017
Applicant:
Nucana Plc, Edinburgh, GB;
Inventors:
Assignee:
NuCana plc, Edinburgh, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7076 (2006.01); A61P 35/00 (2006.01); A61K 31/7072 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 31/7072 (2013.01); A61P 35/00 (2018.01);
Abstract
Provided are medical uses and methods for targeting cancer stem cells employing ProTide compounds, particularly in the prevention or treatment of cancer. The ProTide may be other than one selected from the group consisting of NUC-1031, a ProTide derived from cordycepin, and a ProTide derived from 8-chloroadenosine. The medical uses and methods for targeting cancer stem cells are particularly useful in the treatment of relapsed or refractory cancer in human patients. Also provided are methods of selecting patients who will benefit from prevention or treatment of cancer through the medical uses or methods of treatment of the invention.