The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Oct. 07, 2015
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
David C. Lyden, New York, NY (US);
Bruno Costa Da Silva, Lisbon, PT;
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); G01N 33/574 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
G01N 33/57438 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/46 (2013.01); G01N 2333/70557 (2013.01); G01N 2333/70585 (2013.01); G01N 2333/70596 (2013.01); G01N 2333/715 (2013.01); G01N 2333/90245 (2013.01); G01N 2333/96494 (2013.01); G01N 2800/50 (2013.01);
Abstract
The present invention is directed to a method for identifying an individual who is at risk for developing metastatic liver disease that involves measuring, in a sample isolated from the individual, exosomal levels of one or more markers of metastatic liver disease. Kits for carrying out this method are also disclosed. The present invention also relates to a method of preventing metastatic liver disease in an individual who are at risk for developing the disease that involves administering one or more inhibitors of liver pre-metastatic niche formation.