The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Apr. 28, 2020
Applicant:
Immnogen, Inc., Waltham, MA (US);
Inventors:
Olga Ab, Millis, MA (US);
Neeraj Kohli, Arlington, MA (US);
Thomas Chittenden, Sudbury, MA (US);
Julianto Setiady, Lexington, MA (US);
Assignee:
ImmunoGen, Inc., Waltham, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 31/5365 (2006.01); A61P 35/00 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 31/5365 (2013.01); A61K 47/6803 (2017.08); A61P 35/00 (2018.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01);
Abstract
The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.