The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Mar. 31, 2015
Capitalbio Corporation, Beijing, CN;
Tsinghua University, Beijing, CN;
Yan Liu, Beijing, CN;
Guohao Zhang, Beijing, CN;
Jiang Zhu, Beijing, CN;
Zhengde Feng, Beijing, CN;
Hongju Guo, Beijing, CN;
Jian Gao, Beijing, CN;
Wanli Xing, Beijing, CN;
Jing Cheng, Beijing, CN;
CapitalBio Corporation, Beijing, CN;
Tsinghua University, Beijing, CN;
Abstract
In one aspect, the present disclosure provides an integrated microfluidic device for nucleic acid amplification and microarray detection. In one aspect, the device comprises: (1) a microchip configured to process reagents, comprising a plurality of reservoirs, channels, valves, and/or fluid interfaces; (2) an amplification chamber for PCR, carried out in a detachable tube assembled on the microchip through a joint; and (3) a microarray chamber comprising a microarray and a reaction chamber. In some embodiments, these features are interconnected to allow transportation of reagents for nucleic acid amplification and hybridization detection functions in a closed system. In one aspect, the integrate device herein overcomes the problem of contamination during the amplification and hybridization reactions.