The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Aug. 30, 2019
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/07 (2013.01); A61L 27/50 (2006.01); A61F 2/82 (2013.01); A61L 27/56 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61L 27/507 (2013.01); A61F 2/07 (2013.01); A61F 2/82 (2013.01); A61L 27/56 (2013.01); A61L 31/146 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C12N 5/0692 (2013.01); A61L 2300/252 (2013.01); A61L 2300/412 (2013.01); A61L 2300/42 (2013.01);
Abstract
Provided herein are human arterial endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human arterial endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described.