The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2022
Filed:
Jun. 13, 2018
Applicant:
Adaptive Biotechnologies Corporation, Seattle, WA (US);
Inventors:
Marcos E. Milla, Seattle, WA (US);
Mark Klinger, Seattle, WA (US);
Peter J. R. Ebert, Seattle, WA (US);
Timothy Lee Hayes, Seattle, WA (US);
Edward J. Osborne, Seattle, WA (US);
Joyce K. Hu, Seattle, WA (US);
Assignee:
Adaptive Biotechnologies Corporation, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6881 (2018.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01); C07K 14/47 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6881 (2013.01); A61K 39/001153 (2018.08); C07K 14/4748 (2013.01); C07K 14/7051 (2013.01); C07K 16/30 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/804 (2018.08); C07K 2317/73 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01);
Abstract
The invention is directed to methods for determining antigen-specific T cells generally and to T cell receptors which bind an epitope of the Wilms' tumor antigen-1 (WT1) protein specifically. The disclosure also provides polynucleotides encoding the TCRs, engineered cells exogenously expressing the TCRs, and methods of making and using the TCRs and/or cells expressing the TCRs.