The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2022
Filed:
Jan. 14, 2015
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Mahboobe Ghaedi, New Haven, CT (US);
Laura Niklason, Greenwich, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/36 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0688 (2013.01); A61K 35/36 (2013.01); C12N 5/0689 (2013.01); C12N 2500/99 (2013.01); C12N 2501/115 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/415 (2013.01); C12N 2506/45 (2013.01);
Abstract
The present invention provides compositions and methods of preparing airway cells. In one aspect, an epithelial airway cell derived from an induced pluripotent stem (iPS) cell characterized by expression of airway cell surface markers and an ability to proliferate is described. In another aspect, methods of differentiating an iPS into an epithelial airway cell is provided. Engineered lungs, methods of making such engineered lungs comprising the epithelial airway cells and treating respiratory disorders are also disclosed.