The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2022
Filed:
May. 01, 2020
Applicant:
Wisconsin Alumni Research Foundation (Warf), Madison, WI (US);
Inventors:
Assignee:
Wisconsin Alumni Research Foundation (WARF), Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); A61P 31/16 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 9/007 (2013.01); A61K 9/0019 (2013.01); A61K 39/145 (2013.01); A61P 31/16 (2018.01); C12N 7/00 (2013.01); A61K 2039/54 (2013.01); A61K 2039/544 (2013.01); C12N 2760/16121 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16152 (2013.01);
Abstract
An isolated recombinant influenza virus is provided having PA, PB1, PB2, NP, NS, M, NA and HA viral segments, wherein the PB1 viral segment encodes a PB1 with a residue other than isoleucine at position 711 or the M viral segment encodes a M1 with a residue other than methionine at position 128, wherein the recombinant influenza virus has enhanced replication relative to a corresponding influenza virus having a PB1 viral segment that encodes a PB1 with an isoleucine at position 711 or having a M viral segment that encodes a M1 with methionine at position 128, as well as methods of making and using the virus.