The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2022

Filed:

Dec. 29, 2016
Applicant:

Universidad DE Chile, Santiago, CL;

Assignee:

UNIVERSIDAD DE CHILE, Santiago, CL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 31/04 (2018.01);
Abstract

The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers; pharmaceutical composition; preparation procedure; and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant(MRSA), intermediate vancomycin-resistant(VISA), vancomycin-resistant(VRSA), vancomycin-resistantspp. (VRE),, Emergingwith resistance to linezolid and/or bacterial strains not susceptible to daptomycin. Where the radicals R, R, R, Rand Rare as defined in the work specifications of the present invention.


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