The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2022

Filed:

Mar. 06, 2020
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Jean-Baptiste Blanc, Basel, CH;

Christian Kramer, Basel, CH;

Christian Lerner, Basel, CH;

Matthias Nettekoven, Basel, CH;

Philippe Pflieger, Basel, CH;

Bernd Puellmann, Basel, CH;

Thomas Ryckmans, Basel, CH;

Sébastien Schmitt, Basel, CH;

Min Wang, Shanghai, CN;

Song Yang, Shanghai, CN;

Chengang Zhou, Shanghai, CN;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/454 (2006.01); C07D 401/14 (2006.01); A61P 31/04 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 31/04 (2018.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01);
Abstract

The disclosure provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, Rand Rto Rare as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.


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