The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2022

Filed:

Jul. 03, 2018
Applicant:

University of York, York, GB;

Inventors:

Simon Duckett, North Yorkshire, GB;

Soumya Singha Roy, North Yorkshire, GB;

Kate M. Appleby, Midlothian, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); C07F 15/00 (2006.01); G01R 33/28 (2006.01); G01R 33/56 (2006.01);
U.S. Cl.
CPC ...
A61K 49/106 (2013.01); A61K 49/103 (2013.01); C07F 15/0093 (2013.01); G01R 33/282 (2013.01); G01R 33/5601 (2013.01); G01R 33/5605 (2013.01);
Abstract

There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.


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