The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2022

Filed:

Oct. 30, 2017
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

John Koulakis, Porter Ranch, CA (US);

Seth J. Putterman, Malibu, CA (US);

James C. Dunn, Santa Monica, CA (US);

Joshua Rouch, Santa Monica, CA (US);

Nhan Huynh, San Jose, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61B 17/32 (2006.01); A61M 5/158 (2006.01); A61K 31/00 (2006.01); A61P 17/02 (2006.01); A61P 31/00 (2006.01); A61B 5/055 (2006.01); A61B 6/03 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0019 (2013.01); A61B 17/32 (2013.01); A61K 31/00 (2013.01); A61M 5/158 (2013.01); A61P 17/02 (2018.01); A61P 31/00 (2018.01); A61B 5/055 (2013.01); A61B 6/032 (2013.01); A61B 2017/320004 (2013.01);
Abstract

Methods are taught for treating chronic wounds and skin and soft tissue infections with antibiotic tumescent injection. In such methods, the region of tumescent drug delivery is monitored and expanded by the infusate in order to be 2×-5× larger in area and volume in the region of the wound or infection, the drug in the infusate creates a tissue concentration greater than the MIC in the tumescent volume for selected period of time, and the high concentration has a residence lifetime in the tissue long enough to kill the bacteria. Typically, the methods are performed without the use of vasoconstrictors such as epinephrine and in a manner that avoids physical manipulation of the wound.


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