The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Nov. 30, 2017
Applicant:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Inventors:
Eric R. Schreiter, Ashburn, VA (US);
Luke D. Lavis, Leesburg, VA (US);
Ahmed Abdelfattah, Ashburn, VA (US);
Assignee:
HOWARD HUGHES MEDICAL INSTITUTE, Chevy Chase, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/58 (2006.01); C07K 14/195 (2006.01); C07K 14/215 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01); C07K 14/465 (2006.01); C12N 9/14 (2006.01); G01N 21/64 (2006.01); G01N 33/566 (2006.01);
U.S. Cl.
CPC ...
G01N 33/582 (2013.01); C07K 14/195 (2013.01); C07K 14/215 (2013.01); C07K 14/43504 (2013.01); C07K 14/461 (2013.01); C07K 14/465 (2013.01); C12N 9/14 (2013.01); C12Y 308/01005 (2013.01); G01N 21/6428 (2013.01); G01N 33/566 (2013.01); C07K 2319/60 (2013.01); G01N 2021/6439 (2013.01);
Abstract
Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.