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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11385232 B1

PDFFull Text
Date of Patent:
Jul. 12, 2022

Filed:

Aug. 31, 2018

Phenotypic profiling of hepatocellular carcinoma circulating tumor cells for treatment selection

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Vatche Agopian, Los Angeles, CA (US);

Hsian-Rong Tseng, Los Angeles, CA (US);

Shuang Hou, Los Angeles, CA (US);

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);

Attorneys:

Karen S. Canady

canady + lortz LLP

Primary Examiner:

Gailene Gabel

Int. Cl.
CPC ...
G01N 33/574 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57438 (2013.01); C07K 16/2851 (2013.01); C07K 16/303 (2013.01); G01N 33/54306 (2013.01); G01N 33/54346 (2013.01); G01N 2800/085 (2013.01);
Abstract

Methods and kits for detecting hepatocellular carcinoma recurrence or metastasis, and of measuring markers of hepatocellular carcinoma, including markers of hepatocellular carcinoma recurrence or metastasis, in a blood sample obtained from a subject by (a) isolating circulating tumor cells (CTCs) by contacting a blood sample obtained from the subject with a set of capture antibodies, wherein the capture antibodies specifically bind asialoglycoprotein receptor (ASGPR), Glypican-3, and epithelial cell adhesion molecule (EpCAM); (b) contacting the isolated CTCs with an antibody that specifically binds vimentin; and (c) measuring the number of vimentin-positive CTC.

Find Patent Forward Citations

Agopian, Vatche. (2022). Phenotypic profiling of hepatocellular carcinoma circulating tumor cells for treatment selection (U.S. Patent No. 11385232). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11385232

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