The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2022

Filed:

Feb. 24, 2020
Applicant:

Pacific Biosciences of California, Inc., Menlo Park, CA (US);

Inventors:

Paul Lundquist, San Francisco, CA (US);

Stephen Turner, Seattle, WA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6874 (2018.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01); G02B 6/02 (2006.01); G02B 6/12 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); G01N 21/648 (2013.01); G01N 21/6428 (2013.01); G01N 21/6454 (2013.01); G01N 21/7746 (2013.01); G02B 6/0229 (2013.01); G01N 2021/7789 (2013.01); G01N 2201/08 (2013.01); G02B 2006/12147 (2013.01);
Abstract

Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.


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