The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Mar. 12, 2021
Applicant:
Scinopharm Taiwan, Ltd., Tainan, TW;
Inventors:
Kuan-Hsun Huang, Tainan, TW;
Li-Ting Wang, Tainan, TW;
Inze Lin, Tainan, TW;
Tsung-Cheng Hu, Tainan, TW;
Assignee:
ScinoPharm Taiwan, Ltd., Tainan, TW;
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/56 (2006.01);
U.S. Cl.
CPC ...
C07D 215/56 (2013.01); C07B 2200/13 (2013.01);
Abstract
In certain aspects, the invention provides crystalline forms of ivacaftor N-(2,4-di-tert-butyl-phenyl-5-hydroxy-phenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide. In related aspects, the invention provides a process for preparing any one of crystalline forms S2, S3, S4 and S5 of ivacaftor. The process includes: forming a solution including crude ivacaftor and a solvent; adding an anti-solvent to the solution to form slurry including a precipitate; isolating the precipitate; and drying the precipitate to provide crystalline form S2, S3, S4, or S5 of ivacaftor.