The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Jun. 28, 2018
Applicant:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Inventor:
Suzanne Lentzsch, Bronx, NY (US);
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 43/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 39/39541 (2013.01); A61P 43/00 (2018.01); C07K 16/18 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55 (2013.01); A61K 2039/57 (2013.01); A61K 2039/58 (2013.01);
Abstract
Methods and pharmaceutical compositions for treatment of amyloid deposition diseases using chimeric (e.g., mouse-human) antibody are disclosed, including a method for treating amyloid deposition diseases with cardiac involvement by administering pharmaceutical compositions comprising a chimeric anti-amyloid fibril antibody. The methods herein can improve myocardial function in patients diagnosed with light chain amyloid light chain amyloidosis (ALA) having a cardiac involvement in as little as three weeks after treatment.