The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Sep. 08, 2016
Tsinghua University, Beijing, CN;
Yonghui Zhang, Beijing, CN;
Yun Xia, Beijing, CN;
Yonghua Xie, Beijing, CN;
Zhengsen Yu, Beijing, CN;
Xiaoying Zhou, Beijing, CN;
Xin Li, Beijing, CN;
Liping Li, Beijing, CN;
Yunyun Yang, Beijing, CN;
Kanzhao Gao, Beijing, CN;
Ke Wang, Jiangsu, CN;
Wanli Liu, Beijing, CN;
Meng Zhao, Beijing, CN;
Tsinghua University, Beijing, CN;
Abstract
Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.