The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Jan. 26, 2018
Applicant:
The Methodist Hospital, Houston, TX (US);
Inventor:
Haifa Shen, Bellaire, TX (US);
Assignee:
The Methodist Hospital, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 39/39 (2006.01); A61K 47/69 (2017.01); A61K 47/64 (2017.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 39/001104 (2018.08); A61K 39/001106 (2018.08); A61K 39/001156 (2018.08); A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61K 47/645 (2017.08); A61K 47/6925 (2017.08); A61P 35/00 (2018.01); A61K 9/0019 (2013.01); A61K 9/0021 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55533 (2013.01); A61K 2039/55555 (2013.01);
Abstract
Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines.