The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2022

Filed:

Aug. 23, 2018
Applicants:

Sapporo Medical University, Sapporo, JP;

Sumitomo Pharma Co., Ltd., Osaka, JP;

Inventors:

Toshihiko Torigoe, Sapporo, JP;

Yoshihiko Hirohashi, Sapporo, JP;

Noriyuki Satoh, Sapporo, JP;

Kenjiro Kamiguchi, Sapporo, JP;

Rena Morita, Sapporo, JP;

Satoshi Nishizawa, Sapporo, JP;

Akari Takahashi, Sapporo, JP;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 38/17 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); C07K 7/06 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 38/177 (2013.01); C07K 7/06 (2013.01); C12N 5/0638 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5017 (2013.01); G01N 33/574 (2013.01); G01N 33/57492 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/705 (2013.01);
Abstract

A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.


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