The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Mar. 29, 2018
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Universite DE Rouen Normandie, Mont-Saint-Aignan, FR;
Universite DE Picardie Jules Verne, Amiens, FR;
Centre Hospitalier Universitaire DE Rouen, Rouen, FR;
Centre Hospitalier Universitaire D'amiens, Amiens, FR;
Jeremy Bellien, Rouen, FR;
Isabelle Six, Amiens, FR;
Romuald Mentaverri, Amiens, FR;
Said Kamel, Amiens, FR;
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;
UNIVERSITE DE ROUEN NORMANDIE, Rouen, FR;
UNIVERSITE DE PICARDIE JULES VERNE, Amiens, FR;
CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN, Rouen, FR;
CENTRE HOSPITALIER UNIVERSITAIRE D'AMIENS, Amiens, FR;
Abstract
The inventors demonstrate that the phosphatase and hydrolase domains of soluble epoxide hydrolase (sEH) regulate the cardiovascular calcification process and revealed that inhibition of the phosphatase domain of sEH could represent a new pharmacological target in the prevention of cardiovascular calcification. The present invention thus relates to a therapeutically effective amount of an inhibitor of phosphatase activity of soluble epoxide hydrolase for use in a method of treating cardiovascular calcification in a subject in need thereof.