The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Apr. 19, 2018
Institut D'investigació Biomèdica DE Bellvitge (Idibell), Barcelona, ES;
Institució Catalana DE Recerca I Estudis Avançats, Barcelona, ES;
Aurora Pujol Onofre, Barcelona, ES;
Stéphane Fourcade, Barcelona, ES;
INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL), L'Hospitalet de Llobregat, ES;
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, Barcelona, ES;
Abstract
Therapeutic solutions for axonal degeneration include use of NRF2 activators in prevention and/or treatment of axonal degeneration. A method of prevention and/or treating axonal degeneration includes administering a therapeutically effective amount of a NRF2 activator selected from a GSK3 inhibitor or the compound of formula (I): wherein Rand R, which may be the same or different, independently represent H, a linear, branched wherein Rand R, which may be the same or different, independently represent a linear, branched or cyclic, saturated or unsaturated Calkyl radical, a pharmaceutical salt thereof or a metabolite or precursor of the dimethyl fumarate to a patient in need of the treatment.