The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2022
Filed:
Aug. 29, 2014
Trustees of Boston University, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
James J. Collins, Newton Centre, MA (US);
Sylvain Meylan, Allston, MA (US);
Samuel Moskowitz, Waban, MA (US);
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
Abstract
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.