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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11378540 B1

PDFFull Text
Date of Patent:
Jul. 05, 2022

Filed:

May. 18, 2020

Apparatus and method for measuring concentration of an analyte in bio-samples

Applicant:

I-sens, Inc., Seoul, KR;

Inventors:

Geun Sig Cha, Seoul, KR;

Hakhyun Nam, Seoul, KR;

Seok-Won Lee, Seongnam-si, KR;

Sung Hyuk Choi, Gwacheon-si, KR;

Youngjea Kang, Seoul, KR;

Myeongho Lee, Seoul, KR;

Ho Dong Park, Wonju-si, KR;

Sung Pil Cho, Wonju-si, KR;

Assignee:

I-SENS, INC., Seoul, KR;

Attorney:

Morgan, Lewis & Bockius LLP

Primary Examiner:

Michael Y Sun

Int. Cl.
CPC ...
G01N 27/327 (2006.01); G01N 33/49 (2006.01); G01N 33/487 (2006.01); C12Q 1/00 (2006.01); G01N 33/543 (2006.01); A61B 5/1468 (2006.01); G01N 33/53 (2006.01); B01L 3/00 (2006.01); A61B 5/1495 (2006.01); A61B 5/145 (2006.01); G01N 27/49 (2006.01); G01N 33/26 (2006.01); G01N 33/52 (2006.01); G01N 27/48 (2006.01); G01N 27/42 (2006.01);
U.S. Cl.
CPC ...
G01N 27/3274 (2013.01); G01N 27/3272 (2013.01); G01N 33/48707 (2013.01); G01N 33/49 (2013.01); A61B 5/1468 (2013.01); A61B 5/1495 (2013.01); A61B 5/14532 (2013.01); A61B 2562/0295 (2013.01); B01L 3/5023 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0825 (2013.01); C12Q 1/001 (2013.01); C12Q 1/002 (2013.01); G01N 27/3271 (2013.01); G01N 27/3273 (2013.01); G01N 27/3277 (2013.01); G01N 27/42 (2013.01); G01N 27/48 (2013.01); G01N 27/49 (2013.01); G01N 33/26 (2013.01); G01N 33/4875 (2013.01); G01N 33/48771 (2013.01); G01N 33/52 (2013.01); G01N 33/5302 (2013.01); G01N 33/5438 (2013.01);
Abstract

An apparatus for measuring a concentration of an analyte in a bio-sample using an electrochemical bio-sensor, includes a connector with a sample cell in which an oxidation/reduction enzyme and an electron transfer mediator are fixed and a working electrode and an counter electrode are provided; a digital-to-analog converter circuit configured to apply a constant DC voltage to start the oxidation/reduction reaction of the analyte, proceed with an electron transfer reaction, and apply a Λ-step ladder-type perturbation potential for fluctuating a potential of the sample cell after applying the constant DC voltage; and a microcontroller configured to control the digital-to-analog converter circuit and directly obtain a concentration value of the analyte from a calibration equation using the Λ-step ladder-type perturbation potential. The apparatus can improve measurement accuracy by effectively minimizing a matrix interference effect of a background material in a bio-sample, particularly an inaccuracy caused by a change in hematocrit.

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