The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 05, 2022

Filed:

May. 22, 2019
Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Chanhyuk Kim, Daejeon, KR;

Jun Y. Axup, San Diego, CA (US);

Hwayoung Yun, Daejeon, KR;

Peter G. Schultz, La Jolla, CA (US);

Jennifer Ma, La Jolla, CA (US);

Jiayin Shen, San Diego, CA (US);

Pengyu Yang, San Diego, CA (US);

Assignee:

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 47/54 (2017.01); C07K 16/32 (2006.01); C07K 16/46 (2006.01); A61K 39/395 (2006.01); C07C 275/16 (2006.01); C07C 275/24 (2006.01); C07D 249/04 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 47/542 (2017.08); C07C 275/16 (2013.01); C07C 275/24 (2013.01); C07D 249/04 (2013.01); C07K 16/2803 (2013.01); C07K 16/2806 (2013.01); C07K 16/2851 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/3069 (2013.01); C07K 16/32 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); Y02A 50/30 (2018.01);
Abstract

Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.


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