The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Dec. 21, 2016
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Daniel Powell, Bala Cynwyd, PA (US);
Andrew Tsourkas, Bryn Mawr, PA (US);
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 14/705 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); C07K 14/70521 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/20 (2013.01); C07K 2319/60 (2013.01);
Abstract
The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.