The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Sep. 14, 2021
The Regents of the University of California, Oakland, CA (US);
David A. Nathanson, Los Angeles, CA (US);
Michael E. Jung, Los Angeles, CA (US);
Jonathan Tsang, Los Angeles, CA (US);
Lorenz Urner, Los Angeles, CA (US);
Peter M. Clark, Los Angeles, CA (US);
Timothy F. Cloughesy, Calabasas, CA (US);
Gyudong Kim, Seoul, KR;
The Regents of the University of California, Oakland, CA (US);
Abstract
The present disclosure relates to compounds, compositions and methods for treating cancer, including compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating cancer in the brain, including glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating cancers such as glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.