The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Dec. 12, 2019
Applicant:
Georgia State University Research Foundation, Inc, Atlanta, GA (US);
Inventors:
Binghe Wang, Marietta, GA (US);
Xingyue Ji, Suzhou, CN;
Assignee:
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 321/10 (2006.01); C07D 265/30 (2006.01); C07C 225/06 (2006.01); A61P 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 321/10 (2013.01); A61P 9/00 (2018.01); C07C 225/06 (2013.01); C07D 265/30 (2013.01);
Abstract
The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs. The compounds disclosed herein contain a cyclopentadienone moiety, a non-reactive dienophile, and an enzyme-cleavable tethering moiety connecting the cyclopentadienone moiety to the non-reactive dienophile. Cleavage of the enzyme-cleavable tethering moiety results in conversion of the non-reactive dienophile to a reactive dienophile.