The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2022
Filed:
Dec. 05, 2018
Vanderbilt University, Nashville, TN (US);
Craig W. Lindsley, Brentwood, TN (US);
P. Jeffrey Conn, Nashville, TN (US);
Darren W. Engers, Brentwood, TN (US);
Julie L. Engers, Brentwood, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
Disclosed herein are tricyclic compounds, including 3-(difluoromethyl)-4-methylpyrimido[4',5′:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.