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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11376235 B1

PDFFull Text
Date of Patent:
Jul. 05, 2022

Filed:

Feb. 08, 2017

Inhibitor of inflammasome activation

Applicant:

Kracie Holdings, Ltd., Tokyo, JP;

Inventors:

Shimpei Watanabe, Tokyo, JP;

Ayako Arai, Tokyo, JP;

Yuichi Takajo, Tokyo, JP;

Satoshi Inamasu, Tokyo, JP;

Satoshi Yomoda, Tokyo, JP;

Akiko Ohno, Tokyo, JP;

Yuko Kitahara, Tokyo, JP;

Taisaku Kanatani, Tokyo, JP;

Assignee:

KRACIE HOLDINGS, LTD., Tokyo, JP;

Attorney:

Greenblum & Bernstein, P.L.C.

Primary Examiner:

Michael Barker

Assistant Examiner:

Randall O Winston

Int. Cl.
CPC ...
A61K 36/00 (2006.01); A61K 31/365 (2006.01); A61K 31/7048 (2006.01); A61K 36/28 (2006.01); A61K 36/634 (2006.01); A23L 33/105 (2016.01); A61Q 19/00 (2006.01); A61K 8/97 (2017.01); A61K 8/49 (2006.01); A61P 3/10 (2006.01); A61P 17/06 (2006.01); A61P 25/16 (2006.01); A61P 9/00 (2006.01); A61P 1/16 (2006.01); A61P 27/02 (2006.01); A61P 13/12 (2006.01); A61P 9/10 (2006.01); A61P 29/00 (2006.01); A61P 3/04 (2006.01); A61P 17/10 (2006.01); A61P 25/28 (2006.01); A61P 17/00 (2006.01); A61P 17/14 (2006.01); A61K 8/9789 (2017.01); A61K 8/60 (2006.01);
U.S. Cl.
CPC ...
A61K 31/365 (2013.01); A23L 33/105 (2016.08); A61K 8/49 (2013.01); A61K 8/4973 (2013.01); A61K 8/602 (2013.01); A61K 8/97 (2013.01); A61K 8/9789 (2017.08); A61K 31/7048 (2013.01); A61K 36/28 (2013.01); A61K 36/634 (2013.01); A61P 1/16 (2018.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61P 9/00 (2018.01); A61P 9/10 (2018.01); A61P 13/12 (2018.01); A61P 17/00 (2018.01); A61P 17/06 (2018.01); A61P 17/10 (2018.01); A61P 17/14 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); A61Q 19/00 (2013.01); A23V 2002/00 (2013.01); A23V 2200/30 (2013.01); A23V 2250/21 (2013.01);
Abstract

To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1β released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.

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