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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11376229 B1

PDFFull Text
Date of Patent:
Jul. 05, 2022

Filed:

Dec. 01, 2020

Method of treating or preventing neurodegeneration

Applicant:

Reprise Pharmaceuticals, Inc., New York, NY (US);

Inventors:

Manuel Friese, Hamburg, DE;

Benjamin Schattling, Hamburg, DE;

Karin Steinbach, Geneva, CH;

Marc Freichel, Saarlouis, DE;

Veit Flockerzi, Blieskastel, DE;

Rudi Vennekens, Herent, BE;

Doron Merkler, Chancy, CH;

Assignee:

REPRISE PHARMACEUTICALS, INC., New York, NY (US);

Attorney:

Cozen O'Connor

Primary Examiner:

Yevgeny Valenrod

Int. Cl.
CPC ...
A61K 31/18 (2006.01); A61K 31/00 (2006.01); A61K 31/05 (2006.01); A61K 31/132 (2006.01); A61K 31/196 (2006.01); A61K 31/198 (2006.01); A61K 31/352 (2006.01); A61K 31/365 (2006.01); A61K 31/473 (2006.01); A61K 31/565 (2006.01); A61K 31/4453 (2006.01); A61K 31/566 (2006.01); A61K 31/4402 (2006.01); A61K 45/06 (2006.01); G01N 33/68 (2006.01); A61K 31/64 (2006.01); C12Q 1/6881 (2018.01);
U.S. Cl.
CPC ...
A61K 31/18 (2013.01); A61K 31/00 (2013.01); A61K 31/05 (2013.01); A61K 31/132 (2013.01); A61K 31/196 (2013.01); A61K 31/198 (2013.01); A61K 31/352 (2013.01); A61K 31/365 (2013.01); A61K 31/4402 (2013.01); A61K 31/4453 (2013.01); A61K 31/473 (2013.01); A61K 31/565 (2013.01); A61K 31/566 (2013.01); A61K 31/64 (2013.01); A61K 45/06 (2013.01); C12Q 1/6881 (2013.01); G01N 33/6872 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2500/04 (2013.01);
Abstract

The invention relates to a compound which is effective in inhibiting the function of the TRPM4 ion channel and the use of such compound in treating or preventing a neurodegenerative disease, such as Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, or amyotrophic lateral sclerosis, in a subject. The invention also provides a pharmaceutical composition comprising a TRPM4 inhibitory compound. The invention further relates to in vitro methods for identifying pharmaceutically active compounds that are useful for treating or preventing a neurodegenerative disease.

Find Patent Forward Citations

Friese, Manuel. (2022). Method of treating or preventing neurodegeneration (U.S. Patent No. 11376229). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11376229

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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