The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
May. 14, 2018
Applicant:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Inventor:
Jurg Sommer, Wayland, MA (US);
Assignee:
Bioverativ Therapeutics Inc., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/86 (2006.01); G01N 33/92 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
G01N 33/86 (2013.01); A61K 38/4846 (2013.01); C12Y 304/21022 (2013.01); G01N 33/92 (2013.01); G01N 2333/755 (2013.01); G01N 2333/9645 (2013.01); G01N 2500/00 (2013.01); G01N 2800/224 (2013.01);
Abstract
The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.