The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Nov. 19, 2018
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Harvey Cantor, Boston, MA (US);
Jianmei Wu Leavenworth, Hoover, AL (US);
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); G01N 33/564 (2006.01); C12Q 1/6883 (2018.01); A61K 35/17 (2015.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/564 (2013.01); A61K 35/17 (2013.01); C12Q 1/6883 (2013.01); G01N 33/5023 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/52 (2013.01); G01N 2500/02 (2013.01); G01N 2800/24 (2013.01);
Abstract
Methods for diagnosing and prognosing autoimmune diseases and T cell lymphomas are provided, for example by measuring levels of intracellular osteopontin (OPN-i). Also provided are screening methods for identifying activators and inhibitors of the transcription factor Bcl6, which is involved in T cell activation/differentiation. Other aspects of the disclosure provide methods for enhancing adoptive T cell transfer.