The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2022

Filed:

Sep. 14, 2016
Applicant:

Genfit, Loos, FR;

Inventors:

Raphaël Darteil, Villeurbanne, FR;

Geneviève Cordonnier, Templemars, FR;

John Brozek, Saint-Amand-les-Eaux, FR;

Emilie Praca, Lille, FR;

Fouad Ben Sudrik, Lille, FR;

Assignee:

Genfit, Loos, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); A61P 1/16 (2006.01); A61K 31/192 (2006.01); G01N 33/66 (2006.01); G01N 33/72 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/192 (2013.01); A61P 1/16 (2018.01); G01N 33/66 (2013.01); G01N 33/6893 (2013.01); G01N 33/723 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G01N 2333/78 (2013.01); G01N 2333/8107 (2013.01); G01N 2800/085 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention relates to a method for the diagnosis of non-alcoholic steatohepatitis (NASH), for determining the activity, the stage, or the severity of NASH or for classifying a subject as a potential receiver or non receiver of a treatment of NASH using circulating miRNAs and other blood circulating markers of liver damage, e.g. alpha 2 macroglobulin, HbA1c, N-terminal pro-peptide of collagen type III, miR-34 and miR-200. It also relates to a kit for implementing the method of the invention, and the compounds for use in a method for the treatment of NASH, wherein the subject to be treated is identified, evaluated or classified according to the method of the invention.


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