The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2022
Filed:
Sep. 14, 2020
Applicant:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Inventors:
Tomoyuki Igawa, Shizuoka, JP;
Shinya Ishii, Shizuoka, JP;
Atsuhiko Maeda, Shizuoka, JP;
Takashi Nakai, Shizuoka, JP;
Assignee:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12N 15/10 (2006.01); C07K 16/24 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); C07K 16/244 (2013.01); C07K 16/248 (2013.01); C07K 16/2866 (2013.01); G01N 33/6854 (2013.01); A61K 2039/505 (2013.01); A61K 2039/544 (2013.01); A61K 2039/545 (2013.01); A61K 2039/552 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C12N 2760/16111 (2013.01); C12N 2760/16134 (2013.01); C12N 2770/20071 (2013.01); G01N 2500/00 (2013.01);
Abstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.